The successful Researcher 6 will be responsible for leading a novel series of cancer studies in mice in the Harris lab in the Department of Biochemistry, Molecular Biology, and Biophysics and the Masonic Cancer Center. He/she will maintain a substantial mouse colony and be responsible for handling animals, setting up crosses, administering anti-tumor drugs, and monitoring tumor formation. The ideal candidate will also have experience with pathology, and will be responsible for harvesting tumor tissues and conducting (immuno) histopathological analyses. He/she will also be responsible for culturing cells and engineering cellular genomes using a combination of molecular biology approaches (CRISPR knockout, shRNA knockdown, stable overexpression). He/she will be expected to train undergraduate students to assist with genotyping, maintain meticulous lab notebooks, collaborate with other lab members, document and refine standard protocols (SOPs), and perform other lab assistance and administrative tasks as necessary (reagent purchasing, stock organization, database management, etc.). He/she will report weekly progress to Dr. Harris and will be expected to present 3-4 times per year at lab meetings.
40% Designing crosses, implementing mouse breeding and husbandry schemes, weaning and genotyping animals, administering anticancer drugs, quantifying tumor progression phyenotypically and genotypically
20% Performing pathological examinations including (immuno)histochemistry studies
20% Culturing and manipulating cancer cell lines.
20% Training undergraduate students to assist with animal studies, maintaining meticulous lab notebooks, collaborating with other lab members, documenting and refining standard protocols (SOPs), performing other lab assistance and administrative tasks as necessary (reagent purchasing, stock organization, database management, etc.), reporting weekly progress to Dr. Harris, and presenting 3-4 times per year at lab meetings.
BS degree in Genetics, Microbiology, Pharmacology, Biochemistry, Biology, or related area. MS degree, DVM degree, or PhD degree (or equivalent years of direct research experience) At least 3 peer-reviewed publications including one as first-author. Hands-on experience working with mouse models for human disease. Mouse pathology expertise (ex. necropsy and (immuno)histopathological examinations)
Preferred Qualifications: Hands-on experience with molecular biology procedures (DNA isolation, PCR, gel electrophoresis) Experience preparing and submitting IACUC protocols. Experience mentoring undergraduate students.
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