Posting Summary: The Beirne B. Carter Center for Immunology Research at the University of Virginia seeks a postdoctoral Research Associate to study immune mechanisms of virus control in Michael Brown's laboratory. This project will investigate how NK cells mediate virus control and protection of lymphoid architecture in the mouse spleen during murine cytomegalovirus (MCMV) infection. Previous work uncovered several quantitative trait loci (QTL) that affect the capacity of NK cells to mediate viral clearance and tissue protective effects, but the basis for regulation of these critical NK functions remains unknown (Gillespie et al (2016) PLoS Pathogens 12(2): e1005419). Classical genetics with genetic screening and genome editing, cellular immunology, bone marrow transplantation, immune cell adoptive transfer and molecular biological approaches will be implemented to precisely map, identify and characterize critical genetic modifiers of NK cells. A major goal is to understand how diversity in NK receptors and their ligands, and additional genetic modifiers together shape NK cell functionality, NK impacts on other immune cells, and inflammatory responses during viral infection, which can serve to model genetic effects known to influence clinical outcomes in human patients suffering from chronic viral infection.
The Beirne Carter Center offers a collaborative immunology community and work environment with outstanding research facilities.
Candidates must have an M.D. and/or a Ph.D. degree in Immunology in hand by the start date and additional experience in Biochemistry, Genetics, Microbiology, or Molecular Biology. The individual should be self-motivated and have developed skills in mentoring, written and oral communication, and the design and analysis of experimental questions.
To apply visit https://jobs.virginia.edu and search for Posting Number 0620471. Applicants should complete a candidate profile, and attach a cover letter, CV, statement of research interest, and a list of three references. For questions regarding the position or application process, please contact Michelle Butler at firstname.lastname@example.org.
This position is restricted and contingent upon the continuation of funding. The position will remain open until filled.
The University of Virginia is an equal opportunity and affirmative action employer. Women, minorities, veterans, and persons with disabilities are encouraged to apply.
Founded by Thomas Jefferson, the University of Virginia opened in 1825 as the nation's first public university. A longstanding dedication to preeminence in both scholarship and teaching; top ranking in global satisfaction, collegiality and work/family issues on the COACHE survey of early career faculty; a commitment to excellence that is integrally connected with diversity and a broad array of ben...efits make the University of Virginia a prime choice for both faculty and staff. The University of Virginia is located in the small cosmopolitan city of Charlottesville near the Blue Ridge Mountains, 70 miles from Richmond and 110 miles from Washington, D.C. The University of Virginia remains the No. 2 best public university in the 2013 edition of the U.S. News and World Report rankings. In the 14 years since U.S. News began ranking public universities as a separate category, U.Va. has ranked either No. 1 or No. 2. U.Va. continues to rank in the Top 25 among the best of all national universities, public and private.