UCLA’s Department of Microbiology, Immunology and Molecular Genetics is seeking to fill an Associate Project Scientist position. The Associate Project Scientist candidate will serve as project manager for a clinical trial of gene therapy. They will also perform independent research on studies of gene therapy for blood cell disorders. Specifically, The Associate Project Scientist will lead a team investigating and applying methods for optimal gene addition to human hematopoietic stem cells, performing pre-clinical studies to support regulatory applications and clinical trial associated assays to assess the molecular and biochemical outcomes in gene therapy patients.
The Associate Project Scientist will also be responsible for development and quality control of assays to measure gene transfer and expression, overseeing the team of SRA’s performing these studies, writing reports to support regulatory filings, and writing scientific manuscripts describing the research results. The Associate Project Scientist position is a 12 month non-Senate position.
Interested candidates should apply on-line by May 22, 2017 on this site:
Start date: June 1, 2017 or as soon as mutually agreeable.
Specific Responsibilities include:
Management of clinical trials of gene therapy using hematopoietic stem cells. This includes coordinating vector supply and cell manufacturing to produce patient-specific lots of genemodified stem cells, coordinating regulatory and Sponsor reporting, coordinating clinical personnel activities, and production of required reports to funding agencies, regulatory entities and others. The design, oversight and execution of experimental studies on the transfer and expression of therapeutic genes in hematopoietic stem cells to treat genetic blood cell disorders, and the direction of others in these studies. Supervision of lab scientists performing these studies. This position requires biochemical and molecular biology assays, cell cultures of primary human hematopoietic cells and use of recombinant lentiviral vectors.
Oversee undergraduates, graduate students and new postdoctoral trainees in the lab.
Ability to work on multiple projects efficiently and effectively.
Ability to work independently on scientific projects.
Assist with preparation of grant proposals.
Prepare reports of laboratory investigations suitable for regulatory filings (e.g. with U.S. Food and Drug Administration).
Preparation of manuscripts for publication in scientific journals.
Required to communicate well with other scientists worldwide.
Candidate should have 5-8 years research experience in biochemistry, molecular biology, cell biology and genomics in an academic setting or equivalent.
Candidate should have prior training and direct experience working with molecular biology and hematology assays and culture systems.
Candidate should have extensive experience in recombinant DNA techniques, experimental hematology methods, cell culturing techniques, and quality control and regulatory requirements for presenting data to regulatory agencies.
Experience with clinical trial performance and project management strongly preferred.
The candidate will report directly to the Principal Investigator and will successfully direct others and carry out experiments and analyze the data generated with minimal to no supervision.
The candidate will be required to complete all appropriate safety training as mandated by the campus’s Environmental Health & Safety Office
The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy see: UC Nondiscrimination and Affirmative Action Policy.
University policy is intended to be consistent with the provisions of applicable State and Federal laws. The Department is particularly interested in candidates who have experience working with students from a diverse background and a demonstrated commitment to improving access to higher education for disadvantaged students.
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