Updated: Jan 5, 2021 Location: UC Irvine Campus Job Type: Department: NEUROBIOLOGY AND BEHAVIOR
Job Opening ID: 14253
Reports To: Principal Investigator
Working Title: STAFF RESEARCH ASSOCIATE I
Department: NEUROBIOLOGY AND BEHAVIOR
Bargaining Unit: RX
Payroll Job Code: 009613
Job Location: UCI Campus- Irvine
Percent of Time: 100%
Work Schedule: TBD
Employee Class: Career
Huntington's disease (HD) is a devastating, inherited neurological disorder that causes psychiatric, cognitive and movement deficits. The Thompson laboratory has been engaged in investigating molecular mechanisms that underlie pathogenesis in HD, and more recently ALS and XDP, with the goal of slowing or stopping progression through target identification and validation in multiple model systems. The lab utilizes biochemical and molecular approaches, stem cell modeling, cell culture, and mouse models of disease.
Under supervision, incumbent will be responsible for assisting with mouse breeding and animal preclinical behavioral and molecular studies, stereotaxic transplantations of cells or virus into mice, as well as routine surgeries, dosing, euthanasia, and tissue collection. In addition, incumbent will assist with receiving, distribution and inventory of some supplies and equipment for the laboratory. Position will require providing general support to graduate students, postdocs and technicians in the use of equipment and laboratory procedures, as well as carrying out basic immunofluorescence and immunohistochemistry on cell culture and mouse tissue. With assistance and/or supervision, individual will perform standard molecular biology techniques including but not limited to PCR, agarose and acrylamide gel electrophoresis of proteins and DNA, preparing and maintaining stocks of plasmid DNA, molecular cloning, Western and qPCRs and other protocols as required as general support for lab projects.
Basic knowledge of molecular biology and biochemistry techniques, tissue staining, fluorescent microscopy, data analysis, imaging and computer skills.
Strong communication skills; both verbal and written. Clear and concise communicator. Demonstrated knowledge of molecular biology and biochemistry techniques Demonstrated knowledge of tissue staining, and fluorescent microscopy Strong data analysis, imaging and computer skills.
Experience with common microbiology techniques, in situ hybridization, plasmid maxi & mini preps, genotyping, CRISPR-Cas9, computational analysis of data. Knowledge and experience with standard cell culture, stem cell culturing/biology and differentiations.
Special Conditions Required:
Must be willing to work evenings and weekends with irregular work schedule dependent on the required experimental conditions
Final candidate subject to background check. As a federal contractor, UC Irvine is required to use E-Verify to confirm the work status of individuals assigned to perform substantial work under certain federal contracts/subcontracts.
The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.
UCI provides reasonable accommodations for applicants with disabilities upon request. For more information, please contact Human Resources at (949) 824-0500.
Since 1965, the University of California, Irvine has combined the strengths of a major research university with the bounty of an incomparable Southern California location. UCI's unyielding commitment to rigorous academics, cutting-edge research, and leadership and character development makes the campus a driving force for innovation and discovery that serves our local, national and global communities.