Join us as a scientific leader in quantitative mass spectrometry expanding the use of proteomics in the diagnosis and treatment of human disease!
The newly formed Precision Biomarkers Laboratory at Cedar-Sinai, is seeking a candidate with comprehensive experience in the development of novel, high performance quantitative mass spectrometry workflows for proteins and peptides. You will have access to state-of-the-art LC-MS platforms (Thermo Exploris 480, Sciex 6500+) enabling quantitative proteomic profiling and development of targeted assays using both high and low resolution techniques. To learn more, please visit: Precision Biomarker Laboratories | Cedars-Sinai (cedars-sinai.edu) .
You will be highly motivated, with a proven record of scientific productivity, excellence in communication, collaboration, and enthusiasm to join a growing, dynamic group. Your motivation, innovation, and attention to detail will augment your ability to work collaboratively. You will be expected to contribute to multiple concurrent projects within the objectives of the group.
The Biomedical Scientist leads project development and compliance of all Federal and State accrediting agency including the Food and Drug Administration (FDA) requirements in good manufacturing practices (GMP) for cellular products in Cedars-Sinai Biomanufacturing Center (CBC). Performs process development, validation, and qualifications for cellular production in GMP / good laboratory practice (GLP) environment. Provides guidance, technical expertise, evaluates client processes and makes recommendations for improvement. Plans and assigns projects, monitors work, and identifies issues/problems, and makes plans to resolve problems. Supervises a production team, tissue culture techniques, aseptic technique, and writing standard operating procedures (SOPs), for developing and processing clinical grade and research grade cellular products. Responsible for managing assigned projects and managing associates activities in regulated working environment. Writes and records controlled documents for assigned projects. Performs and trains associates on all current good manufacturing practices (cGMP)/ GLP related activities. Coordinates and assists quality control team with all required testing activities. Provides excellent communication and must have a thorough understand of laboratory and research functions to ensure the success of projects. Reviews and remains current on literature as it relates to clinical/research study. May develop hypothesis and assist in planning steps for the investigative process.
Direct experience developing of state-of-the-art proteomic workflows, developing technology and working independently.
In-depth knowledge of protein chemistry and allied techniques (electrophoresis, western blot, affinity chromatography).
Hands on experience with Thermo and Sciex mass spectrometry platforms.
Familiarity with mass spectrometry analysis software (vendor specific and open source)
Demonstrated scientific productivity and have excellent oral and written communication skills.
Ability to manage multiple projects and timelines.
Bachelor's Degree in molecular biology, microbiology, biochemistry or related science/engineering field required. Doctorate Degree, preferred.
Experience and Skillset:
Eight (8) years experience in GMP/GLP or equivalent regulated facility. Ph.D. with at least three (3) years of professional experience in mass spectrometry driven proteomics, especially in areas with direct application to human health.
Experience with laboratory automation is highly desirable.
Prior experience with immunoaffinity, molecular biology, and/or cell culture is a plus.
Basic familiarity with R or Python for data analysis preferred.
Working Title: Biomedical Scientist - Product Development - Precision Biomarker Lab
Department: Precision Biomarker Labs
Business Entity: Academic / Research
City: Los Angeles
Job Category: Academic / Research, Family & Function
Providing healthcare for more than 100 years, Cedars-Sinai has evolved into one of the most dynamic and highly renowned medical centers in the world. Along with caring for patients, Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. This attracts exceptional talent to Cedars-Sinai, including world-renowned physician-scientists who seek a place where they can both conduct research and see patients--the ideal formula for discovery and its translation into cures. Our patients benefit from access to doctors at the top of their fields, and our researchers have an ideal community in which to study the impact of healthcare challenges, and reflect that knowledge in their research. The greater Los Angeles area in which Cedars-Sinai resides possesses unparalleled cultural and ethnic diversity which offers outstanding opportunities for translational and clinical research and a dynamic environment for medical education.Although community based, Cedars-Sinai is a major t...eaching hospital affiliated with the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Cedars-Sinai has highly competitive graduate medical education programs in more than 50 specialty and subspecialty areas, a graduate program in biomedical sciences and translational medicine, a clinical scholars program directed towards junior physicians with aspirations to become clinical scientists, and post graduate training opportunities.There are more than 250 full-time faculty members at Cedars-Sinai. The voluntary medical staff, comprised of more than 2,200 specialty board-certified or board-qualified physicians, represent all of the specialties and subspecialties and collaborate with full-time medical staff in the teaching responsibilities of the graduate medical education programs.