Lawrence Berkeley National Lab's (LBNL) Biological Systems and Engineering Division has an opening for a Biological Engineering Project Scientist to join the Advanced Biofuels and Bioproducts Process Development Unit (ABPDU) team.
In this exciting role, you will be a part of the Department of Energy's (DOE) Bioenergy Technologies Office (BETO) funded Agile BioFoundry and located at the ABPDU in Emeryville, CA. The Process Integration and Scale-Up task within ABF aims to study cellular heterogeneity in bioreactor cultivation that starts at the inoculum level and rapidly amplifies during cultivation in bioreactors, leading to high levels of variability even among bioreactor replicates. The industry has generally come to accept this high level of variability, often 20%, as a standard for bioprocessing studies. You will design experiments to quantify cell-to-cell heterogeneity in bioreactors and devise solutions to address the variability problem and prolong biocatalysis during fermentation, enabling more robust biomanufacturing processes. This is a highly collaborative project and it is expected that the Project Scientist will be open to working with a number of different groups within and outside the Lawrence Berkeley National Laboratory, including groups at other National Labs and universities. The learnings from these studies will not only be published but also tested with industrial collaborators at the ABPDU.
What You Will Do:
Ability to or willingness to learn and execute bioreactor cultivations and perform a range of phenotypic and biochemical analyses.
Develop single cell reporter assays to monitor key metabolic processes and potential roles in controlling strain productivity under varied experimental conditions.
Collaborate with institutes, such as the Joint Genome Institute and Environmental Molecular Sciences Laboratory, to conduct large-scale whole-genomic next-generation sequencing and -omic analyses.
Strategize and write grants to obtain additional funding on the topic of systems-level microbial heterogeneity occurring during bioreactor cultivation.
Draft manuscripts describing experimental work.
Present results and discuss plans with funders.
What is Required:
0-5 years of relevant experience beyond the highest degree in the field of evolutionary microbiology, systems biology, environmental microbiology, biochemical engineering, chemical engineering, or a similar field.
Previous experience contributing to publications in peer-reviewed journals.
Experience in analyzing and interpreting -omic data with strong quantitative/computational skills.
Experience applying novel approaches to analyzing genomic sequence data.
Familiarity with microbial imaging techniques.
Excellent verbal and written communication skills.
Interest in mentoring and developing others.
Ph.D. degree in the field of evolutionary microbiology, systems biology, environmental microbiology, ecology, biochemical engineering, chemical engineering, or similar field.
Previous experience or interest in employing imaging tools as a method to observe phenotypic changes, such as with fluorescence microscopy, confocal microscopy, or cryoEM techniques to help resolve subcellular localization.
Interest in developing quantum imaging tools for biological systems.
Experience in prokaryotic protein localization analysis.
This is a full time, 1 year, term appointment that may be renewed to a maximum of five years.
This position may be subject to a background check. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment.
Diversity, equity, and inclusion are core values at Berkeley Lab. Our excellence can only be fully realized by faculty, students, and staff who share our commitment to these values. Successful candidates for our faculty positions will demonstrate evidence of a commitment to advancing equity and inclusion.
Work will be primarily performed at Advanced Biofuels and Bioproducts Process Development Unit (ABPDU) -- Bldg. 978, 5885 Hollis St., 3rd floor, Emeryville, CA
Biological Systems and Engineering Division
Vision: To lead efforts that combine the power of biology with the tools of engineering to develop sustainable energy and biomanufacturing solutions and improve human health.
Mission:Advance a mechanistic and predictive understanding of complex biological systems over multiple scales in terms of their responses to manipulation, stress, disease and environmental challenges and translate this knowledge using engineering principles to develop resilient systems, tools, and processes for the efficient production of fuels, chemicals, materials, tissues, and therapeutics.
Berkeley Lab (LBNL) addresses the world's most urgent scientific challenges by advancing sustainable energy, protecting human health, creating new materials, and revealing the origin and fate of the universe. Founded in 1931, Berkeley Lab's scientific expertise has been recognized with 13 Nobel prizes. The University of California manages Berkeley Lab for the U.S. Department of Energy's Office of Science.
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Equal Employment Opportunity:
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In the world of science, Lawrence Berkeley National Laboratory (Berkeley Lab) is synonymous with excellence. Thirteen scientists associated with Berkeley Lab have won the Nobel Prize. Fifty-seven Lab scientists are members of the National Academy of Sciences (NAS), one of the highest honors for a scientist in the United States. Thirteen of our scientists have won the National Medal of Science, our nation's highest award for lifetime achievement in fields of scientific research. Eighteen of our engineers have been elected to the National Academy of Engineering, and three of our scientists have been elected into the Institute of Medicine. In addition, Berkeley Lab has trained thousands of university science and engineering students who are advancing technological innovations across the nation and around the world. Berkeley Lab is a member of the national laboratory system supported by the U.S. Department of Energy through its Office of Science. It is managed by the University of California (UC) and is charged with conducting unclassified research across a wide range of scientific disciplines. Located on a 200-acre site in the hills above the UC Berkeley campus that offers spectacular... views of the San Francisco Bay, Berkeley Lab employs approximately 4,200 scientists, engineers, support staff and students. Its budget for 2011 is $735 million, with an additional $101 million in funding from the American Recovery and Reinvestment Act, for a total of $836 million. A recent study estimates the Laboratory's overall economic impact through direct, indirect and induced spending on the nine counties that make up the San Francisco Bay Area to be nearly $700 million annually. The Lab was also responsible for creating 5,600 jobs locally and 12,000 nationally. The overall economic impact on the national economy is estimated at $1.6 billion a year. Technologies developed at Berkeley Lab have generated billions of dollars in revenues, and thousands of jobs. Savings as a result of Berkeley Lab developments in lighting and windows, and other energy-efficient technologies, have also been in the billions of dollars. Berkeley Lab was founded in 1931 by Ernest Orlando Lawrence, a UC Berkeley physicist who won the 1939 Nobel Prize in physics for his invention of the cyclotron, a circular particle accelerator that opened the door to high-energy physics. It was Lawrence's belief that scientific research is best done through teams of individuals with different fields of expertise, working together. His teamwork concept is a Berkeley Lab legacy that continues today.