Andrew Yang Lab – Junior/Assistant/Associate/Full Specialist

SCHOOL OF MEDICINE – Anatomy

Description

The Yang lab is seeking a Junior/Assistant/Associate/Full Specialist to join our group and contribute to new projects starting January 2022.

Our lab creates new molecular tools to track, decipher, and modulate unexpected communication across the blood-brain barrier (BBB) in order to improve drug delivery to the brain and reveal new mechanisms governing brain health. For example, we adopt various chemical and engineering techniques to catalog BBB-permeable proteins in health and disease. We also apply our new single-cell methods to understand how Alzheimer’s disease risk genes expressed in the human BBB contribute to neurodegeneration. Some recent work include:

• https://www.nature.com/articles/s41586-020-2453-z
• https://www.biorxiv.org/content/10.1101/2021.04.26.441262v1
• https://pubs.acs.org/doi/10.1021/jacs.8b03074

The candidate will contribute to tool development and/or single-cell work in the lab. The candidate will either have or learn a variety of techniques in molecular biology (e.g., cloning, DNA purifications), chemical biology (e.g., click chemistry), cell culture (e.g., transfections, immune co-cultures), mouse work, and high-throughput -omics data analysis/ genetics (RNA-seq, ATAC-seq).

The exceptional candidate will lead their own independent project, develop new ideas, be familiar with the literature, and publish lead author papers, where appropriate. Additionally, the candidate will be expected to assist with managing day-to-day lab operations, and perform general lab duties and be a vital part of a positive lab culture. The lab will enthusiastically support the next steps of candidates’ careers, e.g., pursuing graduate or medical school.

Required Qualifications:

• Excellent organizational and interpersonal communication skills (verbal and written)
• Ability and enthusiasm to learn new methods and skills for changing research priorities.
• Ability to work independently and as a member of a research team.
• Ability to prioritize tasks, coordinate work tasks with others, and meet multiple deadlines.
• Must have (or be in process of obtaining) a bachelor’s degree (or equivalent degree) or four years of research experience to be appointed at the Junior rank.
• Must have (or be in process of obtaining) a master’s degree (or equivalent degree) or at least five to ten years of research experience to be appointed at the Assistant or Associate ranks.
• Must have (or be in process of obtaining) a terminal degree (or equivalent degree) or at least ten or more years of research experience to be appointed at the Full rank.

Preferred Qualifications:

• Experience with molecular and microbiology techniques (including DNA and RNA isolation, PCR, gel electrophoresis, cloning, bacterial transformation etc.)
• Experience with high-throughput sequencing and analysis (RNA & ATAC-seq, eQTL)
• Experience with cell culture (including culturing, aseptic techniques, virus production, transfection etc.)
• Experience handling mice (IP and IV injections, genotyping, tissue/ cell isolation)

We are seeking at least a 1-year commitment. Depending on performance and workload, opportunities for independent research, mentorship of other trainees, and scientific writing will be available.

Applicants must meet requirements by the time of appointment.

UC San Francisco seeks candidates whose experience, teaching, research, or community service that has prepared them to contribute to our commitment to diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.

Please apply online at https://aprecruit.ucsf.edu/JPF03612