A core manager/microscopy scientist is being recruited to scientifically, administratively and technically oversee and manage all microscopes of Columbia Center for Human Development/Center for Stem Cell Therapies (CCHD/CSCT, part of the Department of Medicine), and perform and assist with advanced imaging data analysis. The operator/manager will be responsible for training staff members so they can use the microscopes independently, troubleshooting, assisted use for newer staff members or more complex applications, assisting and training staff members in the proper use of the HIVE server and AIVIA software, liaising with manufacturers for service, repairs and upgrades, enforcing proper usage and maintenance of all equipment, scheduling appointments, and compiling usage data per user to that charge-backs can be implemented quarterly. Importantly, this microscopy scientist should also collaborate with all members to increase sophistication and quality of analysis, develop novel applications to address specific research questions, and participate in the writing of grant applications, in particular of collaborative, multi-PI grants.
The CCHD (Director, Dr. Wellington Cardoso) is currently composed of 7 investigators who use developmental and stem cell biology to deepen our understanding of human disease and develop innovative treatments. A Columbia Center for Stem Cell Therapy (CSCT, Director, Dr. Hans-Willem Snoeck, PI of this application) is currently being established that will share equipment and space with CCHD but will expand through additional recruitment and philanthropy towards translational research into the development of cellular therapies for human disease, with blood, lung and heart as a major focus of both research and fundraising. The members of both centers span several divisions of the Department of Medicine (Pulmonary – Snoeck, Cardoso, Mori, Wang; Gastrointestinal and Liver – Zhao, Que, Yan), as well as basic science departments (Genetics and Development – Cardoso, Yan, Zhao; Microbiology and Immunology – Snoeck), and all labs have access to graduate students from these respective programs and from the Institution-wide Integrated Program.
Imaging, primarily of developmental process and of organoids, is an essential tool in the endeavors of the Centers. To this end, a microscopy core is being built that serves the investigators of the Centers, as well other investigators in the Dept. of Medicine. This core currently consists of two Leica DMi8 inverted fluorescence deconvolution microscopes, a Leica SP8-DLSM microscope that is dedicated to light sheet microscopy of organoids, a Zeiss 710 confocal microscope, a Zeiss live cell Axio Observer inverted modular microscope that allows for automated live cell imaging, a Leica M165 FC fluorescence dissecting stereomicroscope, a Leica Stellaris 8 confocal microscope and an Acquifer HIVE server with AIVA imaging software that is dedicated to data storage and analysis.
Minimum Degree Required: MD or PhD
Minimum Qualifications: Expertise in biological or biomedical research with a focus on high-end microscopy and data analysis
Columbia University is an Equal Opportunity Employer / Disability / Veteran
Columbia University is one of the world's most important centers of research and at the same time a distinctive and distinguished learning environment for undergraduates and graduate students in many scholarly and professional fields. The University recognizes the importance of its location in New York City and seeks to link its research and teaching to the vast resources of a great metropolis. It seeks to attract a diverse and international faculty and student body, to support research and teaching on global issues, and to create academic relationships with many countries and regions. It expects all areas of the university to advance knowledge and learning at the highest level and to convey the products of its efforts to the world.