We are seeking an exceptional, highly motivated and team-oriented Research Scientist to join the Blau Lab in the Baxter Laboratory for Stem Cell Biology, in the Department of Microbiology and Immunology, Stanford University School of Medicine. The successful candidate will work with a multidisciplinary and dynamic research team on aging and regenerative medicine.
We recently published in Science that decreasing the abundance of Prostaglandin E2 (PGE2) triggers premature muscle aging in young mice, and increasing its levels rejuvenates muscles of aged mice. This physiologic shift in PGE2 concentration is mediated by 15-PGDH, the enzyme that degrades PGE2, which appears to be a pivotal molecular determinant of muscle aging. In mice and humans, 15-PGDH expression increases with age. Even brief systemic 15-PGDH inhibition not only augments muscle mass and strength, but also increases time to exhaustion on a treadmill, which suggests a more general amelioration and rejuvenation of aged tissue function.
The position requires a highly self-motivated, accomplished individual with an outstanding track-record of innovation and success in both graduate school and postdoctoral research with a sustained publication record. The successful candidate will contribute primarily to the molecular and cell biology aspects of the lab's efforts. Primary cell culture and rodent models of aging and injury will be a primary tool used by this investigator.
The successful candidate will have a demonstrated history of success in establishing and performing collaborative research with excellent oral and written communication skills and the ability to take initiative, provide strategic input, problem solve and work in teams.
Located between San Francisco and San Jose in the heart of Silicon Valley, Stanford University is recognized as one of the world's leading research and teaching institutions. Leland and Jane Stanford founded the University to "promote the public welfare by exercising an influence on behalf of humanity and civilization." Stanford opened its doors in 1891, and more than a century later, it remains dedicated to finding solutions to the great challenges of the day and to preparing students for leadership in a complex world. The University's thriving diverse community is comprised of nearly 7000 undergraduate students, 12000 graduate students, 2000 faculty members, 1900 postdoctoral scholars, and over 11,000 academic and administrative staff in seven schools including several interdisciplinary research centers and institutes. The campus spreads over 8000 contiguous acres and nearly all undergraduates live on campus. Stanford offers bachelor's and master's degrees in addition to doctoral degrees (PhD, MD, DMA and JD) plus a number of professional and continuing education programs and certifications. More at http://facts.stanford.edu and http://www.stanford.edu. Stanford is an equal empl...oyment opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Stanford also welcomes applications from others who would bring additional dimensions to the University’s research, teaching and clinical missions.