We are seeking a recent PhD graduate or someone with postdoctoral experience to participate in research focused on understanding how herpes simplex virus (HSV) proteins and virus particles are transported in neuronal axons. The position will involve manipulating and producing plasmid DNAs, which will be transfected into neurons cells to produce HSV proteins that are transported into neuronal axons. Other work will involve studies of protein-protein interactions to understand which HSV proteins interact with kinesin motors that transport virus particles in axons. Specific duties include:
Manipulating and producing plasmid DNAs, which will be transfected into neurons to characterize protein transport into axons.
Producing virus stocks and using these viruses to infect neurons.
Passaging and caring for neuronal cell lines and imaging these cells using confocal microscopy in order to determine how viruses and viral proteins are transported into neuronal axons.
Studying interactions between viral proteins and kinesin motors using molecular biologic techniques.
Assisting PI to write scientific papers and grant applications
This position follows the NIH Salary Scale. The Postdoctoral Scholar will work in standard microbiology laboratory conditions, with exposures such as hazardous chemicals and biohazard waste.
PhD in Microbiology, Molecular Biology, Cell Biology or Virology
Ability to perform common laboratory protocols and tissue culture work
Experience with molecular biology: characterizing proteins using polyacrylamide gels and western blots, manipulating plasmid DNAs, cell culture and transfection of cells
Laboratory experience with manipulating and expressing plasmids and with mammalian cell culture and transfection of cells
Experience with handling viruses such as HSV or other viruses and experience with the culturing neurons
Experience with transfecting cells, propagating viruses and culturing neurons
Apply here online. Please be sure to upload a cover letter and resume or CV.
All are welcome
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