The Department of Medicine at the University of California, Irvine, invites applications for a Specialist position in the Associate, or Full Specialist series in the laboratory of Rami Khayat, MD. The lab is focused on investigating the cardiovascular consequences of sleep apnea. The research includes in-vitro studies of the impact of intermittent hypoxia on endothelial cell dysfunction along with microscopy and PCR studies of vascular specimen obtained from patients.
The ideal candidate will oversee the daily operations in this translational research Sleep laboratory including new member training, laboratory compliance, budget management and purchasing; participates in planning, designing and managing research projects; performs analysis of research literature; assists with preparation of grants, publications, abstracts, and presentations; orders and maintains lab supplies and equipment; performs experiments includes preparing biochemical and molecular biology reagents and performing various molecular biology and immunologic assays; participates in clinical and translational research including acquiring biologic specimens, and isolating peripheral blood cells.
Essential duties: Process samples and execute experiments on human tissue and blood including freshly procured vascular and subcutaneous tissue; blood, and serum; performs molecular biology procedures and immunologic assays including: Western blot analysis, immunohistochemistry, ELISA, PCR for mRNA analysis; performs laboratory techniques to isolate endothelial cells, peripheral blood cell lines; and perform and maintain cell cultures
Participates in planning, design, implementation and management of research projects; plans, designs and executes experiments including confocal microscopy and immunohistochemistry techniques; laser capture transfections sequencing, transfection of cell lines with DNA constructs, DNA extraction, cell separation/cultures, cytokines measurement, and immunoblots;
Primarily responsible for daily laboratory operations and laboratory safety compliance; orders and maintains laboratory supplies and lab equipment; maintains laboratory notebooks for quality control and analysis; performs other duties as assigned; prepares and maintains stock biochemical and molecular biology reagents;
Collects, analyzes and interprets research data; performs critical analysis of research literature; assists with preparation of grants, publications, abstracts, and presentations; collaborates with principal investigator to develop general goals of new research projects; constructs manuscripts;
Participate and assist in humans studies including vascular reactivity studies and biopsy procedures; occasionally contact research participants and participate in follow up visit in collaboration with research coordinators.
Rank and salary will be determined based on qualifications and experience. Initial appointments are for one year and renewal is based on availability of support.
The following are required: -CV -Statement of Research -Inclusive Excellence Activities Statement
Qualifications: Associate rank - should possess a master's degree (or equivalent degree) or five to ten years of experience demonstrating expertise in the relevant specialization. Associate Specialists are normally expected to have a record of academic accomplishments, including contributions to published or in-press research in the field and a demonstrated record of University and/or public service. Specialist rank - should possess a terminal degree ( or equivalent degree) or ten or more years of experience demonstrating expertise in the relevant specialization. Specialists at full rank are normally expected to have a significant record of academic accomplishments, including contributions to published or in-press research in the field, professional recognition in the field, and a demonstrated record of University and/or public service.
Preferred qualifications: Ph.D of Science or equivalent combination of education and experience in biomedical research field.
Since 1965, the University of California, Irvine has combined the strengths of a major research university with the bounty of an incomparable Southern California location. UCI's unyielding commitment to rigorous academics, cutting-edge research, and leadership and character development makes the campus a driving force for innovation and discovery that serves our local, national and global communities.