Researcher 6 - Dept. of Microbiology and Immunology
University of Minnesota Twin Cities
Location: Minneapolis, Minnesota
Salary: 54,467.46 - 152,485.17
Internal Number: 358402
The Department of Microbiology is seeking a computational biologist (Researcher 6) to join the Langlois laboratory and the Antiviral Drug Discovery Center (AViDD). The Langlois lab aims to understand how viruses interact with their hosts. To achieve this we use a number of molecular biology, sequencing and computational approaches to analyze large, complex, multidimensional data. AViDD aims to find therapeutic interventions to help prevent and treat future viral pandemics. The Cellular and Organismic Systems Core supports the entire Midwest AViDD Center by coordinating and implementing cell and animal antiviral testing experiments for the entire center. Based at the University of Minnesota, Boston University and the University of Iowa, the Cellular and Organismic Systems Core provides the specialized resources and administrative framework for performing cellular and animal BSL2, BSL3, BSL4 studies. This Core will focus on SARS-CoV-2, Zika virus, Ebola virus and Lassa virus. This core will evaluate validated hits through high throughput screening, evaluate refined compounds for antiviral activity and dose response, the potential for escape, and efficacy in primary human cells. Finally, compounds that demonstrate efficacy in vitro will be evaluated for prophylactic and therapeutic efficacy in relevant animal disease models.
Position Responsibilities: 30% Design and execute generate single cell RNA and next-generation sequencing experiments.
30% Design and perform molecular biology work at scale (RNA extraction, quantification, qRT-PCR, etc.)
Develop new research directions in the fields of virology, molecular biology, and evolutionary biology
Prepare and submit grant applications to fund UMN research.
Prepare and submit manuscripts for publication. Present publications at national conferences representing UMN.
Manage budgets of multiple studies.
10% Mentor and train researchers in the lab on cutting edge sequencing and molecular biology techniques.
10% Duties as assigned to help the mission of the lab.
Required Qualifications: • Advanced degree with strong research and publication record • Significant experience with single cell genomics and next generation sequencing • Proficiency with computational biology tools (eg R, SPSS, Bash, and HPC) • Experience working with large teams of researchers • Experience with advance molecular biology techniques
The University of Minnesota, founded in the belief that all people are enriched by understanding, is dedicated to the advancement of learning and the search for truth; to the sharing of this knowledge through education for a diverse community; and to the application of this knowledge to benefit the people of the state, the nation, and the world.