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Animal Research Technician - Walensky Lab
The Walensky laboratory focuses on the chemical biology of deregulated protein interactions in cancer, metabolism, and infectious diseases. Our goal is to dissect and target pathologic protein interactions using multidisciplinary approaches that include (1) chemical and stapled peptide design, (2) rigorous biochemical, proteomic, and structural characterizations, (3) mechanistic validation in cells and mouse models of disease, and ultimately (4) clinical translation. We emphasize mechanistic biology, including (1) canonical and non-canonical roles of BCL-2 family apoptotic proteins, (2) the p53 and RAS pathways, (3) high priority metabolic, bacterial and viral targets, and (4) novel helix-in-groove interactions relevant to protein structure, function, and drug development.
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