Leiomyosarcoma Initiative - Junior/Assistant/Associate/Full Specialist, UCSF Roybal Lab

SCHOOL OF MEDICINE - Microbiology and Immunology

Description

The mission of the UCSF Leiomyosarcoma Initiative is to support the development of the next generation of cellular therapies to treat this disease. In the Roybal Lab, we engage in translational research in partnership with research groups at UCSF to develop cutting-edge engineered T cell therapeutics and prepare them for the clinic, as well as develop novel cell technologies for future therapeutic solutions.

We are seeking applications for a Scientist to lead early-stage pre-clinical development of novel T cell therapeutic circuits for the treatment of Leiomyosarcoma. This work will range from proof-of-concept studies to IND enabling studies for a phase I clinical trial. This is an excellent opportunity to learn cutting-edge engineered T cell cancer therapy from leading experts in the field and gain highly sought after pre-clinical development experience in the field of cell therapy.

The successful candidate will perform experimental work on protein engineering, primary human T cell culture, lentiviral transduction, and mouse tumor models. The candidate's main responsibilities will include: a) novel assay development, b) in-vitro T cell circuit design and validation, c) establishment of in-vivo tumor models, d) compiling pre-clinical results to support the designation of clinical vector design, and e) leading the in-vitro and in-vivo pharmacology characterization of therapeutic product candidates in collaboration with a process development team towards an IND filling.

The Initiative Scientist will work with other staff in the Roybal Lab and collaborators in developing the necessary assays, protocols and SOPs and execute the experimental work, data analysis and report their findings in presentations and progress reports.

Required Qualifications:

• Junior rank- Must have (or be in process of obtaining) a baccalaureate degree (or equivalent degree) or four years of research experience to be appointed.
• Assistant rank- Must have (or be in process of obtaining) a master's degree (or equivalent degree) or a a baccalaureate degree with three or more years of research experience to be appointed.
• Associate rank- Master's degree in Immunology, Oncology, Bioengineering, Cell Biology, Molecular Biology or related field or five to ten years of research experience.
• Full rank- Terminal degree (or equivalent degree) in Immunology, Oncology, Bioengineering, Cell Biology, Molecular Biology or related field, or ten or more years of research experience.
• Candidates must meet the required qualifications at the time of appointment. Candidate's CV must state qualifications (or if pending) upon submission.

Preferred qualifications and experience:

• Full rank- PhD
• Experience with human CAR T cell engineering preferred
• Experience in Synthetic Biology, specifically in the design of transcriptional circuits and/or protein engineering, is preferred
• Experience using viral (lentiviral, retroviral or AAV) and/or non-viral gene delivery methods (e.g., CRISPR mediated knock-in or targeted genome integration) highly preferred.
• A minimum of 1-2 years mammalian tissue culture and experimental work using mammalian cells
• Experience with flow cytometry and cell sorting required.
• Knowledgeable with modern techniques of molecular cloning.

We are seeking at least a 2-year commitment. Depending on performance and workload, opportunities for independent research, mentorship of other trainees, and scientific writing will be available.

Applicants must meet requirements by the time of appointment.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $53,100-$188,200.

As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.

The University of California is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected status under state or federal law.

As a condition of employment, the finalist will be required to disclose if they are subject to any final administrative or judicial decisions within the last seven years determining that they committed any misconduct.
* "Misconduct" means any violation of the policies or laws governing conduct at the applicant's previous place of employment, including, but not limited to, violations of policies or laws prohibiting sexual harassment, sexual assault, or other forms of harassment, or discrimination, as defined by the employer.
* UC Sexual Violence and Sexual Harassment Policy
* UC Anti-Discrimination Policy
* APM - 035: Affirmative Action and Nondiscrimination in Employment